Senior Biophysicist: Potassium Channel Simulation Specialist

1 week ago


Melbourne, Victoria, Australia beBeeIonChannel Full time $97,150 - $104,280
Researcher Opportunities

An exciting opportunity is available for an outstanding postdoctoral researcher or PhD graduate to investigate the molecular mechanisms of potassium ion channel function and modulation.

The goal of this research project is to describe potassium channel conduction, inactivation, and modulation mechanisms by employing advanced molecular dynamics methods and analysis.

The systems being studied include BK (Big-conductance K), MthK, and KcsA potassium channels.

The expected outcome is an improved description of fundamental mechanisms of ion channel function and how these proteins respond to physiological and/or pharmacological stimuli to control electrical signaling in the body.

  • Molecular dynamics simulations of membrane protein systems
  • Statistical mechanical theory and molecular dynamics simulations for biophysical problems
  • Atomistic simulations of ion channels, particularly potassium channels
  • Experience in using enhanced sampling and free energy methods
  • Expertise in replica methods and advanced analysis methods

This project will be conducted in collaboration with leading experimental researchers in cryo EM and electrophysiology, funded by a prestigious grant from the National Health and Medical Research Council.

This high-impact project has the potential to lead to related publications in top-tier journals such as Nature, providing excellent career possibilities for a talented and driven researcher.

The successful candidate will have access to cutting-edge computational resources and a collaborative research environment that fosters innovation and growth.



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