Molecular Dynamics Specialist in Potassium Ion Channels
1 week ago
An exciting opportunity is available for an outstanding researcher to investigate the molecular mechanisms of potassium ion channel function and modulation.
The aim of this project is to describe potassium channel conduction, inactivation, and modulation mechanisms by employing advanced molecular dynamics methods and analysis.
The systems being studied include BK (Big-conductance K), MthK, and KcsA potassium channels.
The expected outcome is an improved description of fundamental mechanisms of ion channel function and how these proteins respond to physiological and/or pharmacological stimuli to control electrical signaling in the body.
This computational project, in collaboration with leading experimental researchers in cryo EM and electrophysiology, has the potential to be high impact and will provide excellent career possibilities for a talented and driven researcher.
Required Skills and Qualifications- Hold (or be about to complete) a PhD in physics, physical chemistry, or a closely related discipline.
- Have a research background in computation in biophysics, condensed matter physics, or physical chemistry.
- Have experience in atomistic simulations of membrane protein systems, with a strong preference for those with experience in simulations of ion channels, particularly potassium channels.
- Have experience in statistical mechanical theory and molecular dynamics simulations for biophysical problems using existing packages, with strong preference for those with experience in NAMD/VMD and CHARMM.
- Have a background in using enhanced sampling and free energy methods, such as Umbrella Sampling and Free Energy Perturbation, with expertise in replica methods, such as Replica Exchange with Solute Tempering and Metadynamics, and advanced analysis methods, such as Markov State Modelling, being desirable.
This postdoctoral position is funded at RMIT Academic level A6-A8 and comes with a competitive salary package.
How to ApplySelection involves a standard recruitment process. Please apply through the link below.
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Melbourne, Victoria, Australia beBeeSimulation Full time $97,150 - $104,280Research Opportunities in Potassium Ion Channel DynamicsAs a Postdoctoral Researcher, you will investigate the molecular mechanisms of potassium ion channel function and modulation using advanced molecular dynamics methods and analysis. This project involves systems including BK (Big-conductance K), MthK, and KcsA potassium channels.Key Objectives:Design and...
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Melbourne, Victoria, Australia beBeeIonChannelResearch Full time $97,150 - $104,280Job DescriptionThis research project aims to elucidate the mechanisms of potassium channel conduction, inactivation, and modulation through advanced molecular dynamics simulations.Key Responsibilities:Investigate the molecular mechanisms underlying potassium ion channel function and modulation using computational methods.Analyze the behavior of potassium...
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Melbourne, Victoria, Australia CHARMM-GUI Full timeCHARMM is a versatile program for atomic-level simulation ofmany-particle systems, particularly macromolecules ofbiological interest. - M. KarplusPostdoctoral Researcher in hERG Potassium Ion Channel SimulationsDate2025-01-10LocationMelbourne, AustraliaDescriptionThis project represents an exciting opportunity for an outstanding postdoctoral researcher (or...
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Melbourne, Victoria, Australia CHARMM-GUI Full timeCHARMM is a versatile program for atomic-level simulation ofmany-particle systems, particularly macromolecules ofbiological interest. - M. KarplusPostdoctoral Researcher in hERG Potassium Ion Channel SimulationsDate2025-01-10LocationMelbourne, AustraliaDescriptionThis project represents an exciting opportunity for an outstanding postdoctoral researcher (or...
