Postdoctoral Researcher in hERG Potassium ion channel simulations
2 weeks ago
CHARMM is a versatile program for atomic-level simulation of
many-particle systems, particularly macromolecules of
biological interest. - M. Karplus
Postdoctoral Researcher in hERG Potassium Ion Channel Simulations
DateLocation
Melbourne, Australia
DescriptionThis project represents an exciting opportunity for an outstanding postdoctoral researcher (or PhD graduate) to investigate the molecular mechanisms of the cardiac HERG potassium ion channel. The aim of this project is to describe inactivation and drug modulation mechanisms for HERG by employing advanced molecular dynamics methods. This is an NHMRC-funded project in collaboration with researchers at Victor Chang and the University of Chicago. The project will employ cutting-edge computational approaches using supercomputers, alongside structural and functional experiments, to examine HERG channel mechanisms. The work is expected to be high impact, with related projects recently published in Nature and other top journals, and will provide excellent career possibilities for a talented and driven researcher.
Research Fellow (Level A) DetailsPostdoctoral position funded at RMIT Academic level A6-A8. ($97,150 - $104,280 AUD per year + 17% Superannuation). It is expected the postdoc will commence between December 2024 and February 2025.
Minimum RequirementsTo be successful in this position, the applicant must:
- Hold (or be about to complete) a PhD in physics, physical chemistry or a closely related discipline.
- Have a research background in computation in biophysics, condensed matter physics or physical chemistry.
- Have experience in atomistic simulations of membrane protein systems, with a strong preference for experience in simulations of ion channels, particularly potassium channels.
- Have experience in statistical mechanical theory and molecular dynamics simulations for biophysical problems using existing packages, with strong preference for experience in NAMD/VMD and CHARMM.
- Have a background in using enhanced sampling and free energy methods, such as Umbrella Sampling and Free Energy Perturbation, with expertise in replica methods, such as Replica Exchange with Solute Tempering and Metadynamics, and advanced analysis methods, such as Markov State Modelling being desirable.
- Possess strong skills in supercomputing using both CPUs and GPUs, programming/scripting in a Unix environment, MD scripting for advanced simulations and analysis, as well as good visualization skills.
- Demonstrate ability to work well with experimental collaborators to achieve high impact publications.
- Demonstrate experience in paper writing, with the ability to independently form high quality paper drafts being essential.
- Demonstrate experience in conference presentation of research findings.
- Demonstrate high level written and verbal communication skills.
- Possess the ability to work autonomously whilst displaying a strong commitment to work in a team environment, including the demonstrated ability to confidently and effectively work with colleagues.
- Demonstrate ability to meet deadlines and effectively manage varying workloads and respond to changing priorities as required.
Selection involves a standard recruitment process by RMIT University. Please apply through the link below:
Apply Here
For further information, please email:
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Melbourne, Victoria, Australia CHARMM-GUI Full timeCHARMM is a versatile program for atomic-level simulation ofmany-particle systems, particularly macromolecules ofbiological interest. - M. KarplusPostdoctoral Researcher in hERG Potassium Ion Channel SimulationsDate2025-01-10LocationMelbourne, AustraliaDescriptionThis project represents an exciting opportunity for an outstanding postdoctoral researcher (or...
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Melbourne, Victoria, Australia CHARMM-GUI Full timeCHARMM is a versatile program for atomic-level simulation ofmany-particle systems, particularly macromolecules ofbiological interest. - M. KarplusPostdoctoral Researcher in hERG Potassium Ion Channel SimulationsDate2025-01-10LocationMelbourne, AustraliaDescriptionThis project represents an exciting opportunity for an outstanding postdoctoral researcher (or...
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Melbourne, Victoria, Australia beBeeComputationalBiophysicist Full time $97,150 - $104,280Postdoctoral Researcher in Potassium Ion Channel SimulationsThis is an exciting opportunity for a postdoctoral researcher to investigate the molecular mechanisms of the cardiac HERG potassium ion channel.The aim of this project is to describe inactivation and drug modulation mechanisms for HERG by employing advanced molecular dynamics methods.Research...
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Melbourne, Victoria, Australia beBeeIonChannel Full time $97,150 - $104,280Project Overview">CHARMM is a versatile program for atomic-level simulation of many-particle systems, particularly macromolecules of biological interest.">This project presents an exciting opportunity to investigate the molecular mechanisms of the cardiac HERG potassium ion channel using advanced computational approaches.">The goal is to describe...
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Melbourne, Victoria, Australia beBeeBiophysics Full time $97,150 - $104,280Job Title: Investigative Researcher in Cardiac Potassium Ion Channels">This is an exciting opportunity to investigate the molecular mechanisms of the cardiac HERG potassium ion channel. The aim of this project is to describe inactivation and drug modulation mechanisms for HERG by employing advanced molecular dynamics methods.">The project will employ...
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Melbourne, Victoria, Australia beBeeResearch Full time $97,150 - $104,280**Job Opportunity**: An exciting postdoctoral research position is available to investigate the molecular mechanisms of potassium ion channel function and modulation.The aim of this project is to describe potassium channel conduction, inactivation, and modulation mechanisms by employing advanced molecular dynamics methods and analysis.The systems being...
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Melbourne, Victoria, Australia CHARMM-GUI Full timeCHARMM is a versatile program for atomic-level simulation ofmany-particle systems, particularly macromolecules ofbiological interest. - M. KarplusPostdoctoral Researcher in BK and MthK Potassium Ion Channel SimulationsDate2025-01-10LocationMelbourne, AustraliaDescriptionAn exciting opportunity is available for an outstanding postdoctoral researcher or PhD...
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