Investigative Researcher in Cardiac Potassium Ion Channels

3 days ago

Melbourne, Victoria, Australia beBeeBiophysics Full time $97,150 - $104,280

Job Title: Investigative Researcher in Cardiac Potassium Ion Channels

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This is an exciting opportunity to investigate the molecular mechanisms of the cardiac HERG potassium ion channel. The aim of this project is to describe inactivation and drug modulation mechanisms for HERG by employing advanced molecular dynamics methods.

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The project will employ cutting-edge computational approaches using supercomputers, alongside structural and functional experiments, to examine HERG channel mechanisms. This work is expected to be high impact, with related projects recently published in top journals.

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As a postdoctoral researcher (or PhD graduate) in this position, you will have the opportunity to work on a highly ambitious project that involves collaboration with researchers at Victor Chang and the University of Chicago.

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To be successful in this position, the applicant must have a research background in computation in biophysics, condensed matter physics or physical chemistry, and experience in atomistic simulations of membrane protein systems.

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The ideal candidate will have strong skills in supercomputing, programming/scripting in a Unix environment, MD scripting for advanced simulations and analysis, as well as good visualization skills.

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This project represents an excellent opportunity for a talented and driven researcher to develop their expertise in computational biophysics and make significant contributions to the field.

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Selection involves a standard recruitment process by RMIT University. Please apply through the link below.

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Required Skills and Qualifications:

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  • Hold (or be about to complete) a PhD in physics, physical chemistry or a closely related discipline.">
  • Have a research background in computation in biophysics, condensed matter physics or physical chemistry.">
  • Experience in atomistic simulations of membrane protein systems, with a strong preference for experience in simulations of ion channels, particularly potassium channels.">
  • Have experience in statistical mechanical theory and molecular dynamics simulations for biophysical problems using existing packages, with strong preference for experience in NAMD/VMD and CHARMM.">
  • Have a background in using enhanced sampling and free energy methods, such as Umbrella Sampling and Free Energy Perturbation, with expertise in replica methods, such as Replica Exchange with Solute Tempering and Metadynamics, and advanced analysis methods, such as Markov State Modelling being desirable.">
  • Possess strong skills in supercomputing using both CPUs and GPUs, programming/scripting in a Unix environment, MD scripting for advanced simulations and analysis, as well as good visualization skills.">
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Benefits:

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  • Postdoctoral position funded at RMIT Academic level A6-A8.">
  • Expected to commence between December 2024 and February 2025.">
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Others:

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  • Ability to work well with experimental collaborators to achieve high impact publications.">
  • Demonstrate ability to meet deadlines and effectively manage varying workloads and respond to changing priorities as required.">
  • Strong written and verbal communication skills.">
  • Able to work autonomously whilst displaying a strong commitment to work in a team environment.">
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