Simulation Researcher

2 days ago

Melbourne, Victoria, Australia beBeePotassium Full time $97,150 - $104,280

As a postdoctoral researcher in herg potassium ion channel simulations, you will be working on an exciting project that combines cutting-edge computational approaches with experimental collaborations.

Project Overview

This project represents a unique opportunity to investigate the molecular mechanisms of cardiac herg potassium ion channels using advanced molecular dynamics methods.

Research Objectives

The aim of this project is to describe inactivation and drug modulation mechanisms for herg by employing state-of-the-art computational approaches.

This project will utilize high-performance computing resources alongside structural and functional experiments to examine herg channel mechanisms.

Expected Outcomes

The work is expected to have a significant impact, with related projects recently published in top-tier journals.

This project will provide excellent career opportunities for a talented and driven researcher.

Key Responsibilities
  1. Hold (or be about to complete) a PhD in physics, physical chemistry or a closely related discipline.
  2. Have a research background in computation in biophysics, condensed matter physics or physical chemistry.
  3. Have experience in atomistic simulations of membrane protein systems, with a strong preference for experience in simulations of ion channels, particularly potassium channels.
  4. Have experience in statistical mechanical theory and molecular dynamics simulations for biophysical problems using existing packages, with strong preference for experience in NAMD/VMD and CHARMM.
  5. Have a background in using enhanced sampling and free energy methods, such as Umbrella Sampling and Free Energy Perturbation, with expertise in replica methods, such as Replica Exchange with Solute Tempering and Metadynamics, and advanced analysis methods, such as Markov State Modelling being desirable.
  6. Possess strong skills in supercomputing using both CPUs and GPUs, programming/scripting in a Unix environment, MD scripting for advanced simulations and analysis, as well as good visualization skills.
  7. Demonstrate ability to work well with experimental collaborators to achieve high-impact publications.
  8. Demonstrate experience in paper writing, with the ability to independently form high-quality paper drafts being essential.
  9. Demonstrate experience in conference presentation of research findings.
  10. Demonstrate high-level written and verbal communication skills.
  11. Possess the ability to work autonomously whilst displaying a strong commitment to work in a team environment, including the demonstrated ability to confidently and effectively work with colleagues.
  12. Demonstrate ability to meet deadlines and effectively manage varying workloads and respond to changing priorities as required.

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