Senior Research Biophysicist
1 day ago
CHARMM is a versatile program for atomic-level simulation of many-particle systems, particularly macromolecules of biological interest.
hERG Potassium Ion Channel Simulations
About the ProjectThis project represents an exciting opportunity to investigate the molecular mechanisms of the cardiac hERG potassium ion channel. The aim is to describe inactivation and drug modulation mechanisms for hERG by employing advanced molecular dynamics methods.
The project will employ cutting-edge computational approaches using supercomputers, alongside structural and functional experiments, to examine hERG channel mechanisms.
The work is expected to be high impact, with related projects recently published in top journals, and will provide excellent career possibilities for a talented and driven researcher.
Key Requirements- Hold (or be about to complete) a PhD in physics, physical chemistry or a closely related discipline.
- Have a research background in computation in biophysics, condensed matter physics or physical chemistry.
- Have experience in atomistic simulations of membrane protein systems, with a strong preference for experience in simulations of ion channels, particularly potassium channels.
- Have experience in statistical mechanical theory and molecular dynamics simulations for biophysical problems using existing packages, with strong preference for experience in NAMD/VMD and CHARMM.
- Have a background in using enhanced sampling and free energy methods, such as Umbrella Sampling and Free Energy Perturbation, with expertise in replica methods, such as Replica Exchange with Solute Tempering and Metadynamics, and advanced analysis methods, such as Markov State Modelling being desirable.
- Possess strong skills in supercomputing using both CPUs and GPUs, programming/scripting in a Unix environment, MD scripting for advanced simulations and analysis, as well as good visualization skills.
- Demonstrate ability to work well with experimental collaborators to achieve high impact publications.
- Demonstrate experience in paper writing, with the ability to independently form high quality paper drafts being essential.
- Demonstrate experience in conference presentation of research findings.
- Demonstrate high level written and verbal communication skills.
- Possess the ability to work autonomously whilst displaying a strong commitment to work in a team environment, including the demonstrated ability to confidently and effectively work with colleagues.
- Demonstrate ability to meet deadlines and effectively manage varying workloads and respond to changing priorities as required.
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Melbourne, Victoria, Australia beBeeBiophysicist Full time $97,150 - $104,280Opportunity for Senior BiophysicistThis project offers an exciting opportunity for a highly skilled biophysicist to investigate the molecular mechanisms of the cardiac HERG potassium ion channel.Key ResponsibilitiesEmploy advanced computational approaches using supercomputers to examine HERG channel mechanisms.Collaborate with researchers on this...
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