Advanced Researcher Position in Computational Biophysics

An exciting opportunity exists for an outstanding researcher to investigate the molecular mechanisms of potassium ion channel function and modulation.

The project aims to describe potassium channel conduction, inactivation, and modulation mechanisms by employing advanced molecular dynamics methods and analysis.

The systems being studied include BK (Big-conductance K), MthK, and KcsA potassium channels.

The expected outcome is an improved description of fundamental mechanisms of ion channel function and how these proteins respond to physiological and/or pharmacological stimuli to control electrical signaling in the body.

This computational project is part of a collaboration with leading researchers, funded by a reputable organization.

The work is expected to be high impact, with related projects recently published in top journals, providing excellent career possibilities for a talented and driven researcher.

Key Responsibilities:

• Hold (or be about to complete) a PhD in physics, physical chemistry, or a closely related discipline.
• Have a research background in computation in biophysics, condensed matter physics, or physical chemistry.
• Have experience in atomistic simulations of membrane protein systems, with a strong preference for those with experience in simulations of ion channels, particularly potassium channels.
• Have experience in statistical mechanical theory and molecular dynamics simulations for biophysical problems using existing packages, with strong preference for those with experience in NAMD/VMD and CHARMM.
• Have a background in using enhanced sampling and free energy methods, such as Umbrella Sampling and Free Energy Perturbation, with expertise in replica methods, such as Replica Exchange with Solute Tempering and Metadynamics, and advanced analysis methods, such as Markov State Modelling, being desirable.
• Possess strong skills in supercomputing using both CPUs and GPUs, programming/scripting in a Unix environment, MD scripting for advanced simulations and analysis, as well as good visualization skills.
• Demonstrate ability to work well with collaborators to achieve high impact publications.
• Demonstrate experience in paper writing, with the ability to independently form high-quality paper drafts being essential.
• Demonstrate experience in conference presentation of research findings.
• Demonstrate high-level written and verbal communication skills.
• Possess the ability to work autonomously whilst displaying a strong commitment to work in a team environment, including the demonstrated ability to confidently and effectively work with colleagues.
• Demonstrate ability to meet deadlines and effectively manage varying workloads and respond to changing priorities as required.

Requirements

To be successful in this position, applicants must meet the following requirements:

• PhD in physics, physical chemistry, or a closely related discipline.
• Research background in computation in biophysics, condensed matter physics, or physical chemistry.
• Experience in atomistic simulations of membrane protein systems.
• Experience in statistical mechanical theory and molecular dynamics simulations.
• Background in using enhanced sampling and free energy methods.
• Strong skills in supercomputing and programming/scripting in a Unix environment.

About This Opportunity

RMIT University offers an exciting opportunity to work on a cutting-edge project, collaborate with leading researchers, and develop your skills and knowledge in computational biophysics.

We welcome applications from talented and motivated individuals who share our passion for advancing scientific knowledge and improving human health.

This role provides an excellent chance to contribute to groundbreaking research and build a rewarding career in a collaborative and dynamic environment.