PhD position: Translational Brain Cancer—ADCs Targeting Eph Receptors
3 weeks ago
Applications are invited for a fully funded PhD position in the Sid Faithfull Brain Cancer Laboratory, focusing on the development of antibody–drug conjugates (ADCs) targeting Eph receptors in brain cancer. Building on our group's established expertise in Eph receptor biology, the project will centre on candidate targets known to be overexpressed in gliomas, with in-house antibodies already under development or novel candidate antibodies.
Responsibilities- Contribute to the design, generation, and optimisation of novel ADCs and existing in-house antibodies.
- Evaluate candidate ADCs through a combination of molecular and cell biology approaches, including patient-derived cell lines and organoid models.
- Undertake in vivo preclinical testing of ADCs in relevant brain cancer models to assess efficacy and safety.
- Analyse, interpret, and communicate experimental data, contributing to publications and conference presentations.
- Collaborate closely with a multidisciplinary team of researchers and clinicians to advance therapeutic strategies towards translation.
- A completed Honours or Master's degree (or equivalent) in Biochemistry, Molecular Biology, Biomedical Science, Pharmacology, or a related discipline.
- Strong laboratory skills in cell and molecular biology (e.g. cell culture, cloning, flow cytometry, microscopy, Western blotting or related techniques).
- Demonstrated ability to analyse and interpret experimental data.
- Strong written and verbal communication skills, with the ability to work effectively both independently and as part of a team.
- A genuine interest in translational cancer research and developing novel therapeutic strategies.
- Previous experience with in vivo animal work and organoid culture will be considered a strong advantage.
Remuneration: Full-time scholarship of $36,400pa (2025 rate, tax free, indexed annually) for 3 years and 6 months.
For further information: please contact Bryan.Day@qimrb.edu.au
Closing Date: 1 October 2025
To submit an application: use the APPLY button. All applicants must supply the following documents: Resume and Cover letter addressing the selection criteria outlined in the Position Description.
Applicants must be an Australian Citizen, Permanent Resident or hold a valid work permit or visa. Work eligibility will be checked as part of the recruitment process.
What We Offer- State of the art facilities
- Stimulating work setting focused on cutting edge medical research
- Supportive and collaborative team environment
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Brisbane, Queensland, Australia QIMR Berghofer Full timeOverviewApplications are invited for a fully funded PhD position in the Sid Faithfull Brain Cancer Laboratory, focusing on the development of antibody–drug conjugates (ADCs) targeting Eph receptors in brain cancer. Building on our group's established expertise in Eph receptor biology, the project will centre on candidate targets known to be overexpressed...
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