Postdoctoral Researcher

11 hours ago

Adelaide, South Australia SAiGENCI Full time $60,000 - $80,000 per year

Postdoc position #1: Molecular and Cell Biology

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About the project:

We are seeking a highly motivated molecular and cell biologist to lead mechanistic studies in epigenetic regulation. The focus of these studies is to understand how chromatin-modifying complexes regulate gene expression and their implications in cancer. The successful candidate will have on-site access to core equipment for epigenetics such as imaging, flow cytometry, NGS sequencer, etc.

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About you:

We are looking for an experienced molecular and cell biologist with the following essential and advantageous experiences.

Must have

  • Extensive experience in molecular biology and genomics techniques, particularly in studying transcription and epigenetic regulation using mammalian cell lines. Key techniques include IP, IP-MS, ChIP-seq, ATAC-Seq, CUT&RUN/Tag, RNA-seq, RIP, etc.
  • Proven experience in genome editing and genomic engineering using mammalian cell lines.

Advantageous (but not required)​

  • Experience in genetic screens, working with stem cells and mouse models, and knowledge of developmental biology and cancer biology.
  • Skill in coding (R and/or Python) and familiarity with working on Linux-based clusters.

Postdoc position #2: Structural Biology

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About the project:

We are seeking a highly motivated structural biologist to lead projects aiming to understand the structure and function of chromatin-associated complexes involved in gene repression. The candidate will have access to state-of-the-art facilities at Adelaide Microscopy, including multiple transmission electron microscopes (TEM) such as a Glacios 200 kV Cryo-TEM. Additionally, resources available include the Phoenix high-performance computing (HPC), Bragg Crystallography facility, and Adelaide Proteomics Centre. Our collaboration with Monash University further extends our access to advanced 300 kV Titan Krios and Helios 5 UX cryo-FIBSEM. 

​

About you:

We are looking for an experienced structural biologist with the following essential and advantageous experiences.

Must have

  • Extensive biochemistry experience, specifically in expressing and purifying large multi-subunit protein complexes, and analyzing them through in vitro methods.
  • Extensive experience in structural biology techniques, especially with cryo-EM. This includes sample preparation, data collection, computational analysis, and 3D structure determination of protein macromolecules.

Advantageous (but not required)​

  • Experience in the structural, biochemical, and biophysical study of interactions between DNA/RNA/chromatin and protein.
  • Experience in cell culture and various molecular biology techniques.

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