Research Officer Tvru

**Research Officer
- **Make an important contribution to the health of future generations through**

**medical research**
- **Work with a world-leading, independent medical research institute**
- **Located in Westmead**—
**Sydney’s and Australia’s foremost biomedical**
**research precinct**:

- **Salary Range (AU$91,171 - $97,867) + Super + benefits
Children’s Medical Research Institute (CMRI) was Australia’s first dedicated paediatric research
facility and is now one of the nation’s most highly regarded independent medical research centres.
CMRI’s research programs are supported by state-of-the-art facilities and committed research and
support staff. In a collaborative effort with the University of Sydney and the Sydney Children’s
Hospital Network (SCHN), CMRI has built a world-leading gene therapy program, capturing the
entire translational journey from idea to therapeutic reality, including state-of-the0art research
facilities, dedicated Process Development (PD) and clinical viral vector manufacturing facilities.
Aligned with our efforts in the gene therapy space, CMRI has established Australian first Vector
and Genome Engineering Facility (VGEF) dedicated to distribution of viral vectors and gene therapy
tools and reagents, and Translational Vectorology Research Unit (TVRU), which specializes in the
development of novel recombinant adeno-associated viral vectors (rAAV) and gene therapeutics
for the treatment of paediatric genetic conditions. Both laboratories benefit from direct leadership of
Associate Professor Lisowski, an expert in vector-based gene therapy. In addition to highly
dedicated and motivated researchers, our achievements are made possible by a loyal network of
community supporters, highly engaged donors and the very successful Jeans for Genes®
fundraising campaign.

Applications are invited for a Research Officer positions (postdoctoral researchers) in the
Translational Vectorology Research Unit (TVRU) under the direct mentorship of Associate
Professor Lisowski. The newly established project relates to the development of AAV-based gene
therapy strategies to treat cystic fibrosis (CF) as well as development of relevant preclinical models.
The successful applicants will be responsible for working independently and as part of larger
research unit and perform research in the area of lung models, CF and AAV vectorology under PC2
conditions. The work may involve direct interactions with an international commercial partner (the
sponsor of the project).

supervising junior members of the research team, including students. As part of the research
biology assays including, but not limited to, molecular cloning, DNA/RNA purification, qPCR and
manufacturing and purification, including transfections of suspension and adherent cells and vector
purification using gradient centrifugations and FPLC-based methods. In addition, the positions
involve undertaking routine tasks related to the maintenance of the laboratory and preparation of
research projects in the Research Unit.

The applicants must hold a PhD and/or MD degree inclusive of course work in molecular biology or
biotechnology and have at least one years of relevant post-graduate research experience in
ability to work independently, manage multiple (sometimes competing) priorities and integrate
multiple work initiatives into the overall facility goals, while meeting appropriate deadlines.

Preference will be given to applicants with experience related to CF research, design and cloning of
mammalian expression cassettes, working with adeno associated viral (AAV) vectors and experience in
gene editing and bioinformatics. Strong background working with preclinical in vitro and in vivo
models of human lungs is desirable, but not required.

Demonstrated knowledge and experience with both PC and MAC operating systems and
proficiency with Microsoft Office, especially Excel are required. Applications are encouraged from
enthusiastic and motivated individuals with excellent technical ability and communication skills.

You will be provided with a competitive remuneration package in accordance with qualifications and
experience. Additional benefits include the provision of a Public Benevolent Institution salary
packaging scheme and participation in an employer-contributed superannuation fund.

Applications should include a cover letter (citing PV2231), curriculum vitae and contact details

Please direct enquiries regarding the position to A/Prof. Leszek Lisowski, Unit Head TVRU,

**Research Officer
- **Make an important contribution to the health of future generations through**

**medical research**
- **Work with a world-leading, independent medical research institute**
- **Located in Westmead**—
**Sydney’s and Australia’s foremost biomedical**
**research precinct**:

- **Salary Range (AU$91,171 - $97,867) + Super + benefits
Children’s Medical Research Institute (CMRI) was Australia’s first dedicated paediatric research
facility an