Unlocking the Secrets of Ion Channels: A Senior Research Scientist Role

2 days ago

Melbourne, Victoria, Australia beBeeIonChannel Full time $97,150 - $104,280
Senior Research Scientist in Ion Channel Dynamics

An exciting opportunity is available for an outstanding researcher to investigate the molecular mechanisms of ion channel function and modulation. This postdoctoral research project aims to describe potassium channel conduction, inactivation, and modulation mechanisms using advanced molecular dynamics methods and analysis.

The systems being studied include BK (Big-conductance K), MthK, and KcsA potassium channels. The expected outcome is an improved description of fundamental mechanisms of ion channel function and how these proteins respond to physiological and/or pharmacological stimuli to control electrical signaling in the body.

This computational project, in collaboration with leading experimental researchers, is funded by a prestigious organization. The work is expected to be high impact, with related projects recently published in top journals, and will provide excellent career possibilities for a talented and driven researcher.

Key Responsibilities:

  • Hold (or be about to complete) a PhD in physics, physical chemistry, or a closely related discipline.
  • Have a research background in computation in biophysics, condensed matter physics, or physical chemistry.
  • Have experience in atomistic simulations of membrane protein systems, with a strong preference for those with experience in simulations of ion channels, particularly potassium channels.
  • Have experience in statistical mechanical theory and molecular dynamics simulations for biophysical problems using existing packages, with strong preference for those with experience in NAMD/VMD and CHARMM.
  • Have a background in using enhanced sampling and free energy methods, such as Umbrella Sampling and Free Energy Perturbation, with expertise in replica methods, such as Replica Exchange with Solute Tempering and Metadynamics, and advanced analysis methods, such as Markov State Modelling, being desirable.
  • Possess strong skills in supercomputing using both CPUs and GPUs, programming/scripting in a Unix environment, MD scripting for advanced simulations and analysis, as well as good visualization skills.
  • Demonstrate ability to work well with experimental collaborators to achieve high impact publications.
  • Demonstrate experience in paper writing, with the ability to independently form high-quality paper drafts being essential.
  • Demonstrate experience in conference presentation of research findings.
  • Demonstrate high-level written and verbal communication skills.
  • Possess the ability to work autonomously whilst displaying a strong commitment to work in a team environment, including the demonstrated ability to confidently and effectively work with colleagues.
  • Demonstrate ability to meet deadlines and effectively manage varying workloads and respond to changing priorities as required.

Requirements:

  • PhD in physics, physical chemistry, or a closely related discipline.
  • Research background in computation in biophysics, condensed matter physics, or physical chemistry.
  • Experience in atomistic simulations of membrane protein systems.

What We Offer:

  • Opportunity to work on a high-impact research project.
  • Collaboration with leading experimental researchers.
  • Access to state-of-the-art computing facilities.

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