Research Officer

**Together we are making a difference for kids living with genetic disease.**

Children's Medical Research Institute (CMRI) was Australia's first dedicated paediatric research facility and is now one of the nation's most highly regarded independent medical research centres. CMRI's research programs are supported by state-of-the-art facilities and committed research and support staff. In a collaborative effort with the University of Sydney and the Sydney Children's Hospital Network (SCHN), CMRI has built a world-leading gene therapy program, capturing the entire translational journey from idea to therapeutic reality, including clinical viral vector manufacturing facility. Aligned with our growing efforts in the gene therapy space, in 2016 CMRI has established Translational Vectorology Research Unit (TVRU), which specializes in the development and validation of novel recombinant adeno-associated viral vectors (rAAV) and development and translation of individualised gene therapeutics for the treatment of rare paediatric genetic conditions. TVRU benefits from direct leadership of Prof. Lisowski, a world expert in the fields of vectorology and vector-based gene therapies. In addition to highly dedicated and motivated researchers, our achievements are made possible by a loyal network of community supporters, highly engaged donors and the very successful Jeans for Genes fundraising campaign.

**Work with a team of dedicated professionals**

**We are looking for a Research Officer to join our team to**:

- Manage multiple concurrent experiments and will also be involved in supervision and training of junior members of the research team, including students.
- Be responsible for performing a wide range of molecular biology assays including, but not limited to, molecular cloning, DNA/RNA purification, qPCR and ddPCR, blotting and sequencing, including NGS.
- Get involved in design, cloning, production, purification and use of recombinant adeno-associated viral vectors (AAV).
- To do maintenance and manipulation of a wide range of mammalian cell types (immortalized and pluripotent), primary human cells and tissues, cell differentiation and characterisation under BSL2/2+ conditions. Working with animal models may also be required.
- Do maintenance of the laboratory and preparation of standard operating procedures (SOPs).

**A rewarding role in every way**
- Full time role - 37.5 hours per week. 12 months Fixed Term contract to begin with.
- Excellent not for profit tax benefits.
- A flexible and supportive work environment where everyone's contribution is highly valued.

**What can you bring to this role?**
- PhD and/or MD degree and have hands-on experience in molecular cloning, DNA/RNA biology and cell culture.
- Demonstrated the ability to work independently, manage multiple (sometimes competing) priorities and integrate multiple work initiatives into the overall facility goals, while meeting appropriate deadlines.
- Strong neuroscience background and those with direct experience related to design and cloning of mammalian expression cassettes and working with preclinical in vitro and in vivo models.
- Strong background working with viral vectors, especially adeno associated viral (AAV) vectors is desirable, but not required.
- Demonstrated knowledge and experience with both PC and MAC operating systems and proficiency with Microsoft Office, especially Excel are required.
- Applications are encouraged from enthusiastic and motivated individuals with excellent technical ability and communication skills.

We kindly request no unsolicited resumes or approaches from Recruitment Agencies. We will not be responsible for any fees related to unsolicited resumes.

**Benefits**:

- Salary packaging

Work Location: In person