Research Scientist
4 days ago
About the role
We are an ambitious cyanobacterial biologics platform company seeking an outstanding candidate for the role of Research Scientist. As a highly-motivated individual, you will specialise in protein purification and characterisation studies, supporting the design, development, delivery and testing of novel cyanobacterial biologics, including monoclonal antibodies, VLP vaccines, & therapeutic proteins. You will tackle a range of challenges as an integral part of the team, and demonstrate a high degree of flexibility, creativity, and initiative. You will have team work experience, be adaptable, work well collaboratively, and be able to thrive in a start-up environment.
Key responsibilities
- Develop and optimise robust protein purification processes, initially for preclinical use, including monoclonal antibodies, VLPs, and therapeutic proteins
- Support in vitro & preclinical evaluation of biologics, in collaboration with Strain Engineering & Cultivation team & CTO
- Employ purification techniques such as affinity chromatography (e.g., Protein A/G), ion exchange (IEX), hydrophobic interaction chromatography (HIC), size exclusion chromatography (SEC), and tangential flow filtration (TFF)
- Scale protein production processes to meet the needs of in vivo efficacy, toxicology preclinical studies
- Characterise purified proteins using analytical tools including SDS-PAGE, Western blot, ELISA, UV-Vis spectroscopy, DLS, and HPLC/UPLC
- Work cross-functionally with Bondi's strain development and upstream production team to support protein quantification and characterisation for research and preclinical timelines
- Assist in troubleshooting purification challenges and contribute to the continuous improvement of downstream workflows
- Contribute to process documentation to support eventual transfer to GMP manufacturing for future clinical studies
- Updating CTO and Executive on status and timelines for biologics & preclinical material preparation
- Support preclinical material production, in collaboration with preclinical testing collaborators
Education & Experience
Critical
- Ph.D. or M.S. in Biochemistry, Biotechnology, Immunology, Virology, or related area
- Experience purifying proteins for in vivo and/or in vitro studies (e.g. efficacy, PK/PD, toxicology), such as antibodies, VLPs, or therapeutic proteins
- Familiarity with the specific requirements of preclinical protein / mAb / vaccine production
- Strong analytical and problem-solving skills
- Excellent documentation and communication skills, experience working in a team environment
Advantageous but not essential:
- Familiarity with mAb and/or virus-like particle assembly and purification challenges
- Understanding & experience of antibody biophysical characterisation techniques, such as disulfide bond formation, LC/HC assembly, and glycosylation
- Proficiency in operating HPLC and TFF/AKTA chromatography systems
- ELISA-based testing & in vitro / in vivo therapeutic characterisation
- VLP, mAb and therapeutic protein expression and/or, delivery studies
- Conducted preclinical development and/or delivery studies of mAbs, vaccines or therapeutic proteins
Job Type: Full-time
Work Location: In person
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