Research Scientist

4 days ago

University of New South Wales NSW, Australia Bondi Bio Full time $80,000 - $120,000 per year

About the role

We are an ambitious cyanobacterial biologics platform company seeking an outstanding candidate for the role of Research Scientist. As a highly-motivated individual, you will specialise in protein purification and characterisation studies, supporting the design, development, delivery and testing of novel cyanobacterial biologics, including monoclonal antibodies, VLP vaccines, & therapeutic proteins. You will tackle a range of challenges as an integral part of the team, and demonstrate a high degree of flexibility, creativity, and initiative. You will have team work experience, be adaptable, work well collaboratively, and be able to thrive in a start-up environment.

Key responsibilities

  • Develop and optimise robust protein purification processes, initially for preclinical use, including monoclonal antibodies, VLPs, and therapeutic proteins
  • Support in vitro & preclinical evaluation of biologics, in collaboration with Strain Engineering & Cultivation team & CTO
  • Employ purification techniques such as affinity chromatography (e.g., Protein A/G), ion exchange (IEX), hydrophobic interaction chromatography (HIC), size exclusion chromatography (SEC), and tangential flow filtration (TFF)
  • Scale protein production processes to meet the needs of in vivo efficacy, toxicology preclinical studies
  • Characterise purified proteins using analytical tools including SDS-PAGE, Western blot, ELISA, UV-Vis spectroscopy, DLS, and HPLC/UPLC
  • Work cross-functionally with Bondi's strain development and upstream production team to support protein quantification and characterisation for research and preclinical timelines
  • Assist in troubleshooting purification challenges and contribute to the continuous improvement of downstream workflows
  • Contribute to process documentation to support eventual transfer to GMP manufacturing for future clinical studies
  • Updating CTO and Executive on status and timelines for biologics & preclinical material preparation
  • Support preclinical material production, in collaboration with preclinical testing collaborators

Education & Experience

Critical

  • Ph.D. or M.S. in Biochemistry, Biotechnology, Immunology, Virology, or related area
  • Experience purifying proteins for in vivo and/or in vitro studies (e.g. efficacy, PK/PD, toxicology), such as antibodies, VLPs, or therapeutic proteins
  • Familiarity with the specific requirements of preclinical protein / mAb / vaccine production
  • Strong analytical and problem-solving skills
  • Excellent documentation and communication skills, experience working in a team environment

Advantageous but not essential:

  • Familiarity with mAb and/or virus-like particle assembly and purification challenges
  • Understanding & experience of antibody biophysical characterisation techniques, such as disulfide bond formation, LC/HC assembly, and glycosylation
  • Proficiency in operating HPLC and TFF/AKTA chromatography systems
  • ELISA-based testing & in vitro / in vivo therapeutic characterisation
  • VLP, mAb and therapeutic protein expression and/or, delivery studies
  • Conducted preclinical development and/or delivery studies of mAbs, vaccines or therapeutic proteins

Job Type: Full-time

Work Location: In person

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