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This exciting project is focused on uncovering new antibiotics from microbial isolates sourced from soil and other diverse ecosystems. By integrating cutting-edge genomics, metabolomics, and biochemical screening, the team aims to identify novel compounds that target bacterial cell wall biosynthesis.
As a Postdoctoral Research Fellow, you will collaborate with leading experts in natural products chemistry, microbial genomics, and bioinformatics. Your role will involve isolating and cultivating microbes under varied conditions, extracting and characterizing novel natural products, and analyzing biosynthetic gene clusters (BGCs) to uncover their potential for antibiotic production.
- Undertake the cultivation, isolation, taxonomic characterization, and cryopreservation of soil microbes.
- Undertake the analytical scale cultivation of microbes in a microbioreactor and subsequent chemical profiling of microbial solvent extracts, fractions, and pure natural products.
- Undertake large-scale microbial cultivation to produce and use semi-preparative and preparative scale chromatography to isolate pure bioactive microbial natural products.
- Use spectroscopic and chemical analysis to elucidate the structures of microbial natural products.
- Perform genomics analyses, including BGC mining, comparative genomics, and genome assembly.
- Support and contribute to the safe and efficient operations of research group equipment, infrastructure, methodologies, and protocols.
- Accurately document all research activities in lab books and specialist databases.
