Scientist, Oligo Platform Biology

Nazwa biura: USA - Massachusetts - Cambridge
Posted Date: Oct

GSK is seeking a highly motivated Scientist to join the newly established Oligo Platform Biology group. As a key contributor to this team, you will help establish in vitro assays that will enable GSK's internal oligonucleotide screening efforts across a variety of disease targets and oligonucleotide modalities (ASOs, siRNAs, SSOs & RNA editors).

Key Responsibilities:

• Support oligonucleotide drug discovery through the design, optimization and execution of molecular and cell-based assays for portfolio and platform projects
• Culture immortalized/primary cell types, perform transfections and examine genetic perturbations at the RNA/protein level
• Collaborate with team members and cross-functional stakeholders to drive progress and deliver on research milestones
• Analyze experimental data and present findings to group and broader research teams
• Maintain a well-documented electronic laboratory notebook

Why you?Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• MS with 3+ or BS with 5+ years of experience in molecular biology, cell biology, biochemistry or related field.

• Experience in mammalian cell culture techniques, including plating and transfection of nucleic acids in high-throughput formats (96-well and 384-well plates).

• Experience in molecular biology techniques, including protein & nucleic acid extraction, electrophoresis, PCR, RT-qPCR and digital PCR (dPCR).

• Experience in protein expression analysis using methods such as western blot, ELISA, flow cytometry and immunofluorescence

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Industry experience in a biotech or pharmaceutical setting is preferred.
• Hands-on experience with in vitro models for extrahepatic tissues (e.g., CNS, kidney, lung) is highly desired.
• Familiarity with automated western / ELISA platforms (e.g., Jess, Ella) and liquid handlers (e.g., Viaflo 96/384) is a plus.
• Previous experience in assay development and in oligonucleotide therapeutics (e.g. ASO, siRNA, SSO, RNA Editors) is preferred.
• Sense of urgency, flexibility, independence and accountability.
• Ability to communicate both verbally and in writing with all levels both inside and outside of organization.
• Maintain a high level of integrity while balancing multiple priorities and responsibilities.
• Must be a committed team player prepared to work in and embrace a team-based culture.

#LI-GSK

The US annual base salary for new hires in this position ranges from $89,100 to $148,500 The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Please visit  GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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