Research Officer

The
_Immunology & Immunodeficiency Lab_ is leaded by Prof Stuart Tangye and is focussed on understanding the molecular and cellular requirements necessary for generating successful immune responses following infection and/or vaccination and how these processes are disrupted by specific genetic defects. Specifically, we study individuals with immune diseases such as early-onset and recurrent infections, autoimmunity or allergy and strive to identify genetic causes of these conditions. The overall goal is to elucidate molecular, biochemical, and cellular mechanisms responsible for clinical presentation and using this information to guide treatments or predict disease outcomes.

THE OPPORTUNITY

The Research Officer, Level 1 to 3, is accountable for conducting independent experiments within their Research Pillar in a collaborative framework with their supervisor. In principle, an RO conducts research work under the guidance of a more senior scientist and they would be demonstrating increasing independence as they progress from RO1 to RO3.

**Salary**: Up to $87,082 PA + 10.5% Super + Salary Packaging

Employment Type: 18 month contract

SNAPSHOT OF BENEFITS- Generous salary packaging to save you income tax on your wages thereby boosting your monthly take home pay (max. $15,900 general expenses + $2,650 meals/accom)- Ample opportunities for on-going training and development- Stimulating, diverse and highly international research environment- Flexible work arrangements e.g. location, start / finish times etc- 18 weeks paid parental leave for both parents including paid superannuation- A range of additional leave types to meet your personal needs including cultural leave, conference leave, community service and study leave- Discounted Health Insurance- Lifestyle discounts with our community partners

WHAT YOU WILL DO

RESEARCH OFFICER - LEVEL 1

Performs under guidance

An RO1 would conduct original research under limited supervision, and be required to make contributions in more than one of the following areas:
- Completion of research projects in an efficient and timely manner, with outcomes published under joint authorship in peer-reviewed journals- Contribution to team and Garvan research projects- Presentation of original research at national/ international scientific conferences, and as invited to seminars locally and/or nationally- Co-supervision and mentoring of students and junior research staff- Provision of supervisory assistance in preparation of research grant proposals, including contribution of data- Contribution to improvements in techniques, quantitative methods and quality control- All staff are required to comply with Garvan’s workplace polices (as amended from time to time) and especially Garvan’s Work Health & Safety (WHS) Policy, including working in accordance with the WHS management system at all times, as safety is Garvan’s number one priority.

ABOUT YOU

The general experience requirements are as follows, however this alone is not sufficient. Research Officers (RO) are appointed within the RO 1-3 scale based on their skills, experience and achievements, as well as the scope and demands of the position to which they are appointed.

The key skills and experience of a Research Officer include:
- PhD in immunology, cell biology, molecular biology or biochemistry, with a strong interest and understanding of all of these disciplines as they relate to immunology- Extensive experience with wet laboratory techniques is expected including:
- Isolation of human immune cells from peripheral blood and tissues,-
- In vitro cell culture of primary immune cells and cell lines-
- Multi-parameter flow cytometry and analysis using relevant software,-
- Application of in vitro bioassays to investigate functional responses of immune cells and cell lines established from patients, and healthy donors (eg ELISAs, ELISPOTS, cytokine bead arrays, cell tracking dyes, western blotting)-
- Biochemical and molecular skills such as immunoprecipitation, chromatin immunoprecipitation, gene cloning, qPCR, RNA-Seq and data analysis-
- Implementing assays to test expression and function of recombinant proteins in relevant in vitro systems,-
- CRISPR/Cas9-gene targeting in cells/cell lines to silence genes of interest, and restore gene expression by transfection/gene transfer-
- Knowledge of bioinformatics and analysis- Strong problem solving and analytical skills- Have a strong commitment to continuous delivery of high quality work- Have excellent communication skills for written reports and oral presentations- Demonstrate a capacity to work collaboratively with researchers across laboratories- Be well organised and a good time manager with sound administrative abilities

ABOUT GARVAN

The Garvan Institute of Medical Research is an independent Medical Research Institute (MRI) in Sydney, delivering scientific and clinical impact on a global basis and in partnership with organisations that share our vision. We are pr