Expert Gene Editing Process Developer

2 weeks ago

Brisbane, Queensland, Australia beBeeScientist Full time $157,000 - $178,000

Mammoth Biosciences is a biotechnology company leveraging proprietary ultracompact CRISPR systems to develop curative therapies and applications in precision diagnostics.

Job Description

We are seeking a skilled Scientist II or Senior Scientist I to join our CMC team in a hands-on, cross-functional role that blends scientific expertise with operational excellence.

This position plays a critical role in developing, optimizing, scaling, and characterizing LNP-based delivery production processes for gene editing platforms.

  • Develop and optimize LNP manufacturing processes by applying Quality by Design (QbD) principles and executing Design of Experiments (DoEs) to identify and control critical process parameters (CPPs).
  • Optimize analytical methods such as DLS, Ribogreen, HPLC-CAD, IP-RP-HPLC, and endotoxin to identify and access critical quality attributes (CQAs).
  • Interpret analytical data to assess process robustness and guide iterative development efforts.
  • Collaborate with internal teams to support process improvements and drive innovation.
  • Present scientific findings and project updates effectively in internal meetings and to external collaborators.
  • Drive technology transfer activities with external partners by preparing comprehensive technical documentation.
Required Skills and Qualifications

The ideal candidate will possess:

  • A Ph.D. in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, or a related field with minimum 3 years relevant industry experience; or M.S. with 6 years; or B.S. with 8 years.
  • Demonstrated expertise in LNP formulation and process development, including hands-on experience with microfluidic and high-shear mixing technologies.
  • Proficiency in analytical characterization techniques for LNPs, including DLS, fluorescence-based assays, and HPLC/UPLC methods.
  • Experience with in-process and drug product stability studies.
  • Proven success in applying DoEs and statistical analysis tools for process optimization.
Benefits

Our organization offers:

  • Company-paid health, vision, and dental benefits.
  • Unlimited vacation and generous sick time.
  • Company-sponsored meals and snacks.
  • Wellness, caregiver, and ergonomics benefits.
  • 401(k) with company matching.
Others

We strive to provide an inclusive and supportive work environment.

Equal opportunity employer.

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