Research Officer

4 weeks ago

Bundoora, Australia The Walter and Eliza Hall Institute of Medical Research Full time

Job Title

Research Officer

**Job Description**:
An exciting opportunity is available for a Research Officer to join the WEHI Protein Production Facility at Bundoora within the Advanced Technology and Biology Division. WEHI Protein Production Facility is focused on producing high-quality recombinant proteins for biochemical and cell-based assays, antibody and nanobody generation, structural biology studies, _in vivo_ studies and more.

About the Position

The Protein Production Facility aims to support WEHI researchers and provide bespoke target proteins and biologics to boost the discovery and development of novel therapeutics. This position will be located at WEHI’sBundoora site where the facility is located.

The successful applicant will have extensive experience in multiple aspects of protein biochemistry, including construct design, recombinant protein expression and purification optimization and scale-up, and biochemical and biophysical characterisation methods. Prior experience with mammalian, insect and bacterial cell expression systems for recombinant protein production is required. Experience in analysing protein structure and utilising modern modelling software for protein structural prediction will be highly regarded, as will experience in the production of membrane proteins and large macromolecular complexes.

Selection Criteria

Essential Knowledge and Skills:
- A PhD or equivalent qualification in a relevant discipline such as Biochemistry- Demonstrated experience in construct design, optimization, scale-up expression, and purification of a variety of recombinant proteins- Demonstrated broad range of protein biochemical skills (e.g., cloning, recombinant expression and purification using AKTA systems)- Demonstrated experience in the successful production of proteins in mammalian, insect, and bacterial expression systems- Demonstrated experience in biophysical methods for protein characterisation- Demonstrated ability and potential for excellence and productivity in research

Desirable Knowledge and Skills:
- Experience in SEC-MALS- Experience in protein structural analysis and modelling- Experience in producing recombinant membrane proteins and large macromolecular complexes- Experience in automation and the development of high-throughput protein production workflows- Experience in native protein purification and non-canonical expression systems

Personal Qualities:
- Excellent interpersonal communications skills and the ability to liaise with staff and research students, professional/ technical staff and understand the complex requirements of scientists- Excellent time and quality management skills with a demonstrated ability to perform complex tasks, troubleshoot, and prioritize multiple projects- Demonstrated operations and organisational planning such as examining, developing, and implementing new strategies, procedures, and workflows- Ability to execute experiments accurately and with high competence- Adaptable and willing to provide training to other staff members, learn new systems and procedures as required- Work effectively within a team and individually- Accurate recording of results

Terms of Appointment

General enquiries can be directed to Dr Marija Dramicanin


A position description is available

here


How to Apply

Application Closing Date: 12 April 2024.

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