Postdoctoral Researcher in Chromatin Biology
3 weeks ago
Salary Range: (Level A) $78,544 to $105,611 or (Level B) $111,031 to $131,335 per annum, with an additional employer contribution of 17% superannuation.
Position Type: Fixed term, full-time role available for 24 months.
The 3D Chromatin Organisation Lab, led by Dr. Joanna Achinger-Kawecka, is on the lookout for a postdoctoral researcher to delve into the intricate relationship between chromatin architecture, epigenetics, and transcriptomics. Candidates should possess a solid background in epigenetics and/or chromatin research, a commendable publication history, and a strong drive to independently develop their research initiatives.
Research Focus: Our lab investigates how alterations in 3D chromatin structure contribute to cancer initiation, progression, and therapeutic resistance. Utilizing advanced methodologies such as multi-omics, single-cell analysis, and genome editing, we aim to elucidate the interactions between 3D chromatin, the epigenome, and the transcriptome in cancer contexts. We specifically utilize hormone-responsive cancers to design experiments that enhance our understanding of cancer biology and expedite the creation of novel therapeutic strategies.
Project Overview: The successful candidate will employ state-of-the-art experimental and bioinformatics techniques to explore the dynamic and specific organization of 3D chromatin in cancer cells, focusing on its interactions with non-coding elements and transcription factors.
Key Responsibilities:
- Implement and refine innovative genomics technologies (e.g., Hi-C, RNA-seq, CUT&RUN/Tag, ATAC-seq, WGBS, Nanopore).
- Analyze high-throughput next-generation sequencing (NGS) data.
- Develop novel strategies for integrating data across multi-omics datasets.
- Supervise student research projects at various academic levels.
- Prepare reports and research publications, as well as grant applications, and actively participate in conferences and workshops to present findings.
Qualifications for Level A:
- PhD in a relevant biological discipline (molecular biology, biochemistry, genetics, or related fields) or nearing completion.
- Hands-on experience with a variety of standard molecular and cellular biology techniques, including mammalian cell culture, nucleic acid extraction, and chromatin analysis.
- Ability to quickly acquire new techniques and creatively address experimental challenges.
- Strong problem-solving skills and a solid understanding of basic statistical principles.
- Excellent communication skills, both written and verbal.
Qualifications for Level B:
- PhD in a relevant field (Biology, Genetics, Biomedicine, Bioinformatics, Computational Biology, etc.).
- Proficiency in molecular biology and genomics technologies, particularly regarding chromatin structure, transcriptomics, or epigenetics, as well as integrative analysis of experimental datasets (e.g., 3D Genome, RNA-seq, ChIP-seq/CUT&RUN/Tag, DNA methylation, chromatin accessibility).
- Strong publication record demonstrating independence in research.
- Experience with mammalian cell culture techniques.
- Programming skills in at least one language (preferably R or Python) and familiarity with NGS data processing pipelines are highly desirable.
Work Environment:
The University of Adelaide offers a stimulating workplace characterized by a diverse range of educational and research programs, including significant collaborations with industry, government, and community partners. This environment provides ample opportunities for a rewarding and long-lasting career.
We pride ourselves on attracting high-caliber individuals across all areas of our operations, ensuring a collaborative atmosphere with talented colleagues, many of whom are leaders in their fields. The innovative nature of our work across various disciplines serves as a continuous source of inspiration.
Our culture values diversity and inclusion, aligned with our Staff Values and Behaviour Framework, emphasizing integrity, respect, collegiality, excellence, and discovery. We believe our people are our greatest asset and are committed to enhancing the skills, knowledge, and capabilities of our staff.
We also promote flexibility to help our employees balance the demands of work and personal life.
Faculty Overview:
The Faculty of Health and Medical Sciences encompasses one of Australia's largest groups of leading health researchers, educators, and clinical professionals. It includes eight schools and various specialized disciplines, institutes, and centers focused on world-class research and training the next generation of health professionals.
Commitment to Diversity:
The University of Adelaide is an Equal Employment Opportunity employer dedicated to fostering a work environment that values diversity and inclusion. We strongly encourage applications from female candidates, individuals with disabilities, and Aboriginal and Torres Strait Islander peoples who meet the position requirements.
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