Postdoctoral Researcher in BK and MthK Potassium ion channel simulations.

CHARMM is a versatile program for atomic-level simulation of
many-particle systems, particularly macromolecules of
biological interest. - M. Karplus

Postdoctoral Researcher in BK and MthK Potassium Ion Channel Simulations

Date

2025-01-10

Location

Melbourne, Australia

Description

An exciting opportunity is available for an outstanding postdoctoral researcher or PhD graduate to investigate the molecular mechanisms of potassium ion channel function and modulation. The aim of this postdoctoral research project is to describe potassium channel conduction, inactivation, and modulation mechanisms by employing advanced molecular dynamics methods and analysis. The systems being studied include BK (Big-conductance K), MthK, and KcsA potassium channels. The expected outcome is an improved description of fundamental mechanisms of ion channel function and how these proteins respond to physiological and/or pharmacological stimuli to control electrical signaling in the body. The computational project, in collaboration with leading experimental researchers in cryo EM and electrophysiology, is funded by the National Health and Medical Research Council. The work is expected to be high impact, with related projects recently published in Nature and other top journals, and will provide excellent career possibilities for a talented and driven researcher.

Research Fellow (Level A) Details

Postdoctoral position funded at RMIT Academic level A6-A8. ($97,150 - $104,280 AUD per year + 17% Superannuation). It is expected the postdoc will commence between December 2024 and February 2025.

To be Successful in This Position, the Applicant Must:

1. Hold (or be about to complete) a PhD in physics, physical chemistry, or a closely related discipline.
2. Have a research background in computation in biophysics, condensed matter physics, or physical chemistry.
3. Have experience in atomistic simulations of membrane protein systems, with a strong preference for those with experience in simulations of ion channels, particularly potassium channels.
4. Have experience in statistical mechanical theory and molecular dynamics simulations for biophysical problems using existing packages, with strong preference for those with experience in NAMD/VMD and CHARMM.
5. Have a background in using enhanced sampling and free energy methods, such as Umbrella Sampling and Free Energy Perturbation, with expertise in replica methods, such as Replica Exchange with Solute Tempering and Metadynamics, and advanced analysis methods, such as Markov State Modelling, being desirable.
6. Possess strong skills in supercomputing using both CPUs and GPUs, programming/scripting in a Unix environment, MD scripting for advanced simulations and analysis, as well as good visualization skills.
7. Demonstrate ability to work well with experimental collaborators to achieve high impact publications.
8. Demonstrate experience in paper writing, with the ability to independently form high-quality paper drafts being essential.
9. Demonstrate experience in conference presentation of research findings.
10. Demonstrate high-level written and verbal communication skills.
11. Possess the ability to work autonomously whilst displaying a strong commitment to work in a team environment, including the demonstrated ability to confidently and effectively work with colleagues.
12. Demonstrate ability to meet deadlines and effectively manage varying workloads and respond to changing priorities as required.

How to Apply

Selection involves a standard recruitment process by RMIT University. Please apply through the link below:

Apply Here

For further information, please email: toby.allen@rmit.edu.au

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