Postdoctoral Research Fellow

7 months ago

North Ryde, Australia Macquarie University Full time

PRIMARY DETAIL

Opportunity for an experienced postdoctoral researcher with strong background in molecular biology and a keen interest in neuroscience for designer gene therapy vector development in the Dementia Research Centre.

THE ROLE- Salary Package: Level A, Step 6-8 (PhD $102,501-$109,852) plus 17% Superannuation and annual leave loading- Appointment Type: Fixed Term employment for 12 months (with possible extension contingent to funding available)- Location: Macquarie University (Wallumattagal Campus, North Ryde)

The Dementia Research Centre is seeking an experienced and highly motivated Postdoctoral Research Fellow to drive a FightMND project aiming to develop and transform experimental gene therapy vectors into a human trial-ready gene therapy. This project aims to demonstrate its pre-clinical efficacy and safety profile required for advancing to first in human trials.

The researcher will humanise an experimental gene therapy vector into a translational vector that meets regulatory requirements. The role will be required to optismise processes to produce vector quantities to preclinical validation and future clinical trials. The research will also be required to perform pre-clinical vector validation in MND mouse models and target engagement in iPSC-derived CNS organoids. This project aims to demonstrate its pre-clinical efficacy and safety profile required for advancing to first in human trials. Furthermore, the researcher will develop new gene delivery vectors.

Specific role requirements:
- Undertake molecular biology experiments such as: RT-PCR, DNA/RNA extractions, molecular cloning and modification of DNA plasmids.- Administer and test gene therapies in a range of mouse models. This includes testing, sample collection and monitoring of mice and analysis of data.- Culture and analyse cells, including primary murine and stem cell-derived human neurons.- Analyse biological samples using biochemical and histological techniques.- Maintain and monitor a mouse colony to a high standard. This includes setting up of breedings, monitoring pregnancies, weaning offspring, tissue harvesting, record keeping and genotyping of mice.- Record keeping of experiments and data. Preparation of internal and external presentations and reports.

About You

About Us

The Faculty of Medicine, Health and Human Sciences (FMHHS) is ambitiously pushing the boundaries of progressive thinking and challenging what’s possible to solve some of the big issues of our time, both nationally and on a global scale. The Faculty forms part of MQ Health, an integrated academic health sciences enterprise which incorporates Macquarie University Hospital and primary and speciality clinics. We have active research programs in neurosciences, health systems and patient safety research, cancer medicine, and clinical sciences, amongst others. We foster a values-based culture of innovation and creativity to achieve excellence in teaching and to enhance the research performance of the University. We invest in developing the careers and wellbeing of our students and staff and expect all our leaders to live our values of Caring, Integrity, Teamwork, Ambition, Innovation, and Engagement.

Within the Faculty, the Dementia Research Centre provides an environment for innovative, interdisciplinary research for dementia and other neurological conditions, using and developing state-of-the-art technologies to advance basic discoveries towards translation into clinical treatments. The Dementia Research Centre is committed to providing a unique and supportive mentoring program to allow the growth of future leaders for dementia research.

Macquarie is a university engaged with the real and often complex problems and opportunities that define our lives. Since our foundation 54 years ago, we have aspired to be a different type of university. Over the years, we’ve grown to become the centre of a vibrant local and global community.

Connect with us today

and learn more about the

Dementia Research Centre


To Apply

Essential Criteria:
- PhD in Science in the fields of neuroscience, immunology, virology or cancer biology (or related fields); ideally with prior experience in gene therapy.

Core Criteria:
- Proven experience in the molecular biology techniques such as cloning, CRISPR and phage-display- Proven experience in cell biology techniques such as FACS and cell culture- Proven experience in functional characterization of novel constructs using cellular assays- Proven experience with producing, handling and modifying adeno-associated virus (or other laboratory viruses)- A strong record of contributions to peer reviewed publications and history of research excellence, relative to experience and opportunity.- Excellent written and verbal communication skills with an ability to prepare reports and manuscripts for publication in high impact quality journals.- Proven ability to conduct research independently and as part of a team- Computer skills including

  • Postdoctoral Research Fellow or Research Fellow in

    4 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL - Work with leading academics and researchers - Build your academic networks - Full-time, 2 years, fixed term- Developing model visualisation methods to enable interactive and dynamic model building;- Robust selection and estimation in regression type models;- Variable selection and inference for statistically challenging data, including for...

  • Postdoctoral Fellow

    3 weeks ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL Salary Package: Postdoctoral Fellow (Level A, Step 6) $106,089 per annum, plus 17% employer's superannuation and annual leave loading. Appointment type: Full-time, fixed-term position for 2 years (with the possibility of extending for another two years) Location: Macquarie University (Wallumattagal Campus, North Ryde) Postdoctoral Fellow in...

  • Postdoctoral Research Fellow

    2 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL Postdoctoral Research Fellow in Functional Time Series Analysis - Appointment Type: Full-time, fixed-term (up to 4 years) - Work with leading academics and researchers - Build your academic networks - Innovative and supportive environment The Role- Developing tools to visualize functional panel data, also known as high-dimensional functional...

  • Postdoctoral Research Fellow/research Fellow

    1 week ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL We are seeking talented, enthusiastic researchers, with strong health services/health informatics research skills to participate in an exciting program of research funded by an MRFF grant relating to quality measurement and evaluation in aged care. THE ROLE- - Appointment type: Full-time or part-time, fixed-term position for 2 years (with...

  • Postdoctoral Research Fellow

    4 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL Postdoctoral Research Fellow in the field of neurodegenerative disease research to join the Motor Neuron Disease Research Centre within the Faculty of Medicine, Health and Human Sciences. THE ROLE- Salary Package: From $109,897 (Level A) p.a., plus 17% employer's superannuation and annual leave loading- Appointment Type: Full-time, fixed...

  • Postdoctoral Research Fellow

    5 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL- Salary Package: Postdoctoral Research Fellow (Level A), from $84,437 to $113,697 plus 17% employer's superannuation and leave loading- Appointment Type: Full-time (1.0 FTE) fixed-term position for two years- Location: Macquarie University (Wallumattagal Campus, North Ryde) THE ROLE As part of this role, you will have the unique opportunity...

  • Postdoctoral Research Fellow

    7 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL - Salary Package: From $102,501 - $109,852 (Level A, Step 6 to Step 8) or from $115,787 - $136,995 (Level B) p.a., plus 17% employer's superannuation and annual leave loading - Appointment Type: Full-time, fixed term position for 2 years (with the possibility of extension). - Location: Macquarie University Wallumattagal Campus (North...

  • Postdoctoral Research Fellow

    7 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL - Salary Package: From $102,501 - $109,852 (Level A) or from $115,787 - $136,995 (Level B) p.a., plus 17% employer's superannuation and annual leave loading - Appointment Type: Full-time, fixed term position for 2 years (with the possibility of extension). - Macquarie University (North Ryde) location (Motor Neuron Disease Research Centre) THE...

  • Postdoctoral Research Fellow

    3 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL - Build your academic networks and access cutting-edge facilities and technology - Work Location: Macquarie University and Central Coast Primary Industries Centre, Ourimbah, Australia Macquarie University is seeking a highly motivated and skilled Postdoctoral Research Fellow to work on a Grains Research and Development Corporation (GRDC)...

  • Postdoctoral Research Fellow in Auditory Signal

    4 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL Seeking a postdoctoral fellow to lead the development of a low-cost hearing screening device, funded by the Cochlear-Macquarie University Joint Fund. This position offers a unique opportunity to conduct impactful research alongside a multidisciplinary team of hearing scientists, signal processing experts, and mathematicians, all focused on...

  • Research Fellow

    1 month ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL - Research Fellow A-C Levels, Salary $109,897 - $168,275 - Contributing to the development of the leaching process by assisting project members in necessary laboratory investigations. - North Ryde location; Full time, 3 year fixed term role We have an excellent opportunity for two Research Fellows/Senior Research Fellows, to join the research...

  • Research Fellow in High Performance Mixed Signal

    2 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL - Exceptional development opportunity working with world class researchers - Build your academic networks and access cutting-edge facilities and technology - Full-time, 2 year fixed-term with possibility of renewal An excellent opportunity exists for a researcher to join the newly created Silicon Platforms Lab (SiP Lab) within the School of...

  • Mixed-methods Researcher

    3 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL We are seeking a Mixed-Methods Researcher to be part of a team that brings together healthcare consumers, clinicians, health and medical researchers to improve children’s healthcare. The Role- Salary range: Level A, $106,089 - $113,697 p.a. or Level B, $119,839 - $141,790 p.a. (pro rata) plus superannuation.- Fixed-term, full-time until 31...

  • Research Fellow

    3 days ago

    North Adelaide, Australia South Australian Health and Medical Research Institute (SAHMRI) Full time

    **Full-time, 3 year contract $90,000 to $100,000 pa, depending on experience** **SAHMRI Women and Kids Theme** - **Fast-track your career by joining a highly successful team of researchers**: - **Strong desire to improve health outcomes through high quality research**: - **Interest in nutrition to improve human health**: - **World-class health and...

  • Research Fellow in Quantum Information

    3 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL - Collaboration with leading researchers - Build your academic networks - Competitive salary and benefits You will be part of a team working on projects in quantum measurements and the characterisation of quantum devices. You will join the research group of A/Prof Alexei Gilchrist (6 PhD Students) and collaborate closely with Prof. Kavan Modi...

  • Early Career Fellow

    4 months ago

    North Ryde, Australia Macquarie University Full time

    PRIMARY DETAIL - Salary Package: Level A $84,437 - $113,697 p.a plus 17% employer’s superannuation and annual leave loading - Appointment Type: 3 year fixed-term, full-time (35 hours per week) - Location: Wallumattagal campus, Macquarie University, North Ryde, NSW - Flexible work arrangements may be considered, including flexible work schedules, start and...

  • Fellow/advanced Training, Neonatal Medicine, Wchn

    7 months ago

    North Adelaide, Australia SA Government -SA HEALTH Full time

    **SA Health** **Job reference**: 864849 **Location**: 5006 - NORTH ADELAIDE **Job status**: Long Term Contract **Eligibility**: Open to Everyone - **Women's and Children's Health Network, Women's and Babies Division - Neonatal Medicine - North Adelaide 5006.**: - **Southern Adelaide Local Health Network - Women's and Babies Division - Neonatal and...

  • Wchn Advanced Trainee

    7 months ago

    North Adelaide, Australia SA Government -SA HEALTH Full time

    **SA Health** **Job reference**: 866789 **Location**: 5006 - NORTH ADELAIDE **Job status**: Long Term Contract **Eligibility**: Open to Everyone - **Women's and Children's Health Network** Community, Primary and Population Health, Paediatric Forensic Medical Service (PFMS) - North Adelaide (5006)**: - **Classification - MDP2 - Medical Practitioner -...

  • Wchn Advanced Trainee/fellow Paediatric Haematology

    7 months ago

    North Adelaide, Australia SA Government -SA HEALTH Full time

    **SA Health** **Job reference**: 866939 **Location**: 5006 - NORTH ADELAIDE **Job status**: Long Term Contract **Eligibility**: Open to Everyone - **Women's and Children's Health Network, Division of Paediatric Medicine, Haematology / Oncology - North Adelaide (5006)** - **Salary - Total Indicative Remuneration - $105,155 to $170,687 (includes award...

  • Wchn Advance Trainee

    7 months ago

    North Adelaide, Australia SA Government -SA HEALTH Full time

    **SA Health** **Job reference**: 866947 **Location**: 5006 - NORTH ADELAIDE **Job status**: Long Term Contract **Eligibility**: Open to Everyone - **Women's and Children's Health Network, Division of Sub-Acute and Allied Health, Palliative Care - North Adelaide (5006)**: - **Salary - **Classification - MDP2 - Medical Practitioner - $105,155 to...